Hope that helps

I generally prefer to run the Pod output into a small but clean-sounding solid-state bass amp - I feel it cuts some of what I hear as 'digital artifacts' in the emulated sound. But I've also had good luck just running the line out into the PA front-of-house via balanced-to-XLR connector. I know guys who run the Pod through Fender tube amps, and it can work fine, but I don't like it as much for steel. The tube amp also colors the sound, sometimes too much to me. If I use the tube amp, I generally turn the AIR speaker modeling off. I also have a MusicMan HD-130 (solid-state pre, 6CA7 output) which also works well with the Pod, in fact probably better than the Fenders.

Does the Pod 2 sound as good as a Dual Showman Reverb into a real nice, say JBL D-130 cabinet, or a real good-sounding Session/LTD 400, allowed to get loud enough to get into the working range of the amp? Perhaps not. But for lower-volume gigs, I think it works great, and stays pretty clean if not pushed too hard. The Tweed and British-style models can give a distorted slide-guitar approach, again without pushing tons of stage volume. One nice thing, in small club settings, I no longer having sound men yelling at me to turn down. If anything, they tell me to turn up now. If you knew me, you'd know that's a nice change. It also handles the steel/guitar/banjo switches great without lugging a lot of equipment. That versatility is worth the price of admission, to me.

That Blackface #2 setting is quite clean. I expect it's possible for some hot pickups/active-volume-pedals to overdrive the input section, but I haven't had that problem. I use a passive Goodrich volume pedal, just a hair of compression, and the on-board spring reverb emulation. Sometimes I also use a smidgen of delay.

If you would find it helpful, I'll be happy to email you my settings. You might find them useful as a starting point. But these things do require some tweaking. I have different settings for my MSA, which likes thinner tone settings, and the BMI and Sierras, which like slightly thicker tone settings.

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MSA Classic D-10 8+4, Sierra U-14 8+5, Sierra S-10 3+4, BMI S-10 3+4 plus assorted six-stringers;
Peavey LTD 400, Line6 Pod 2.0 + Ampeg BA 112, '64 Fender Deluxe Reverb, '69 Dual Showman Reverb + EVM Cabinet

You get BF #1 by simply selecting "Blackface" with the Amp Model Switch. You get BF #2 by depressing and holding down the "Tap" button, then switching to "Blackface". As I said, BF1 is Deluxe Reverb, BF2 is Twin Reverb. The Deluxe model is dirtier and more midrangey. The Twin model is cleaner, and I like it much better for steel.

I don't know if the XT programs will work on a POD but they can be downloaded from my site and loaded via the Line 6 edit program.
http://web.tampabay.rr.com/jstoner1